Catheter Gene Delivery
نویسندگان
چکیده
One approach to gene therapy for human cancer is transcatheter injection of DNA liposomes into tumor masses. T o determine the feasibility of selective delivery of recombinant genes by a catheter to the pulmonary vasculature in humans, a patient with melanoma received two treatments of H L A B 7 plasmid D N A complexed to cationic liposomes into a right posterior basal pulmonary artery associated with a mass lesion. The treatments were well tolerated. N o adverse respiratory, cardiac, immunologic, or other organ toxicities were detected. The delivery of recombinant genes by catheter m a y be a useful modality to treat h u m a n malignancy
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